منابع مشابه
The mechanochemistry of molecular motors.
A theory of molecular motors is presented that explains how the energy released in single chemical reactions can generate mechanical motion and force. In the simplest case the fluctuating movements of a motor enzyme are well described by a diffusion process on a two-dimensional potential energy surface, where one dimension is a chemical reaction coordinate and the other is the spatial displacem...
متن کاملThe Origin of Minus-end Directionality and Mechanochemistry of Ncd Motors
Adaptation of molecular structure to the ligand chemistry and interaction with the cytoskeletal filament are key to understanding the mechanochemistry of molecular motors. Despite the striking structural similarity with kinesin-1, which moves towards plus-end, Ncd motors exhibit minus-end directionality on microtubules (MTs). Here, by employing a structure-based model of protein folding, we sho...
متن کاملThe physics of molecular motors.
Molecular motors convert chemical energy into mechanical force and movement. Operating at energies just above those of the thermal bath, these motors experience large fluctuations, and their physical description must be necessarily stochastic. Here, motor operation is described as a biased diffusion on a potential energy surface defined by the interactions of the motor with its track and its fu...
متن کاملMolecular motors
The " Molecular Motors " Minisymposium focused mainly on the microtubule-based motors kinesin and dynein and a class V myosin. A common feature of all these motors is that they move processively on their track, meaning that the motor can take multiple steps without dissociating. A common theme of the Minisymposium was motor function in a complex intracellular environment. Kathy Trybus (Universi...
متن کاملMolecular Motors
Perhaps the most fascinating proteins that associate with the cytoskeleton are the molecular motors called motor proteins. These remarkable proteins bind to a polarized cytoskeletal filament and use the energy derived from repeated cycles of ATP hydrolysis to move steadily along it. Dozens of different motor proteins coexist in every eucaryotic cell. They differ in the type of filament they bin...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2000
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(00)76615-x